Evidence map›Paper›PMID 41070779›Full record

ArticleGlia2026

Oligodendroglial Densities and Myelin Structure Are Altered in TDP-43 Related Amyotrophic Lateral Sclerosis.

Katherine N Lewis, Georgina A Craig, Joel Mason, Doris Tomas, Brittany Cuic, Adam K Walker, David G Gonsalvez, Bradley J Turner, Samantha K Barton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katherine N LewisThe Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.ORCID 0000-0003-2244-1803
Georgina A CraigLi Ka Shing Knowledge Institute, Unity Health, St Michael's Hospital, Toronto, Canada.ORCID 0000-0003-3104-210X
Joel MasonThe Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
Doris TomasThe Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
Brittany CuicThe Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
Adam K WalkerClem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, Brisbane, Australia.
David G GonsalvezDepartment of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.
Bradley J TurnerThe Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
Samantha K BartonThe Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.

Funding

Bethlehem Griffiths Research Foundation Grant BGRF2002FightMND Discovery Project Grant DIS-202303-00887Jane Frances Hayes and Frederick William Hayes Charitable Trust Project GrantMotor Neuron Disease Research Australia PhD Top-Up ScholarshipNational Health & Medical Research Council (NHMRC) Ideas Grant 2001675Rebecca L. Cooper Al & Val Rosenstrauss Medical Research Fellowship
6 · The paper itself

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons. However, the surrounding glia, including oligodendrocytes, also exhibit ALS pathology and TDP-43 related dysfunction. Given that oligodendrocytes, the myelinating cells of the central nervous system, are essential for motor neuron function, they may play an underappreciated role in ALS. Here, we have extensively characterized the oligodendrocyte lineage and myelin integrity in the TDP-43

Indexed as

Amyotrophic Lateral SclerosisDNA-Binding ProteinsMyelin SheathOligodendrogliaAnimalsApoptosisCell DifferentiationCell ProliferationDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLMice, TransgenicSpinal CordDNA-Binding ProteinsTardbp protein, mouseamyotrophic lateral sclerosis (ALS)myelinoligodendrocyteTDP‐43

Identifiers

PMID41070779
PMCPMC12667226

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.