ArticleJournal of cosmetic dermatology2025
UV-A Radiation Impairs Sebaceous-Gland-Related Skin Barrier Function by Inducing Inflammation and Altering Intracellular Sebum-Like Lipid Composition.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Lifestyle factors affecting the pathogenesis of androgenetic alopecia: a literature review.Frontiers in public health · 2026Review
- UV-A Radiation Impairs Sebaceous-Gland-Related Skin Barrier Function by Inducing Inflammation and Altering Intracellular Sebum-Like Lipid Composition.Journal of cosmetic dermatology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSebaceous glands (SGs) secrete sebum to form a protective barrier that maintains skin health. However, exposure to ultraviolet A (UV-A) radiation damages the skin barrier, leading to dryness and inflammation.
aimsIn this study, we investigated how UV-A radiation alters SG function, focusing on inflammation and changes in the composition of intracellular sebum-like lipids. We also explored the role of SG-related mechanisms in UVA-radiation-induced skin barrier damage.
methodsHuman primary sebocytes were cultured from SGs isolated from human skin samples and exposed to different doses of UV-A radiation. Inflammatory cytokines released into the culture medium were measured, followed by gene expression analysis using mRNA extracted from cells to examine specific target genes. Intracellular sebum-like lipid composition was analyzed using liquid chromatography-tandem mass spectrometry, and skin barrier function was evaluated using a three-dimensional reconstructed human epidermis (3D skin) model.
resultsUV-A irradiation increased inflammatory cytokine levels in the culture medium and altered the expression levels of several genes. Intracellular sebum-like lipid composition was also modified following UV-A irradiation, with notable sex differences. Furthermore, the skin barrier function was impaired in 3D skin models cultured with the supernatant from UV-A-irradiated sebocyte cultures.
conclusionsThis study demonstrated that UV-A radiation stimulated sebocytes to release inflammatory cytokines and altered gene expression. Additionally, UV-A irradiation modified the intracellular sebum-like lipid composition in a sex-dependent manner, contributing to skin barrier damage.
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