Molecular Insights into the Astringency of

Inês E Silva, Joana Vieira, Carlos Guerreiro, Joana Oliveira, Elsa Brandão, Victor de Freitas, Susana Soares

Abstract read

In one paragraph

Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Yeast Protein Extract Emulsions Supplemented with Polyphenolic Compounds: Physical, Chemical and Stability Properties of Colorful Emulsions.Antioxidants (Basel, Switzerland) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Inês E SilvaREQUIMTE, LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal.ORCID 0009-0006-6902-3253

Joana VieiraREQUIMTE, LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal.ORCID 0009-0007-0044-0304

Carlos GuerreiroREQUIMTE, LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal.

Joana OliveiraREQUIMTE, LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal.ORCID 0000-0002-9996-1463

Elsa BrandãoREQUIMTE, LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal.

Victor de FreitasREQUIMTE, LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal.ORCID 0000-0003-0586-2278

Susana SoaresREQUIMTE, LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, s/n, Porto 4169-007, Portugal.ORCID 0000-0001-8518-9479

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astringency is a key sensory attribute in plant-based products, often linked to phenolic compounds, such as anthocyanins and flavonols. This study explores the molecular basis of astringency in butterfly pea flower tea using a cell-based model comprising human saliva, oral mucosal pellicle, and HSC3 oral epithelial cells. Specifically, it aimed to (i) assess the contribution of oral constituents to phenolic compound binding (ternatins, flavonols); (ii) evaluate compound-specific interactions; and (iii) determine the influence of pH. Significant interactions with HSC3 oral cells were observed, though inhibited by salivary proteins. Structural features of phenolic compounds also modulated interactions:

Indexed as

AstringentsClitoriaPhenolsPlant ExtractsEpithelial CellsHumansHydrogen-Ion ConcentrationMouth MucosaSalivaTasteAstringentsPhenolsPlant Extractsanthocyaninsastringencyflavonolsoral cell-based modeloral cellssalivary proteins

Identifiers

PMID41070763

DOI10.1021/acs.jafc.5c06189

PMCPMC12818758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.