ArticleCancer2025
Incidence of chronic medical conditions among survivors of adolescent and young adult cancer compared to a population without cancer.
Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Understanding and advancing alignment of the national standards for cancer survivorship care for adolescents and young adults: challenges and opportunities.Journal of cancer survivorship : research and practice · 2026Review
- Article
- Symptom burden among long-term survivors of young adult cancer: a report from the Project Milestones cohort.Journal of cancer survivorship : research and practice · 2026Article
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Authors and funding
17 authors.
Funding
Abstract
backgroundFew studies have assessed the burden of chronic medical conditions in adolescent and young adult (AYA) cancer survivors. This study estimated the risk of these conditions among AYA survivors compared to a matched cohort without cancer.
methodsThis retrospective cohort study included 2-year survivors (n = 14,917) of 11 common AYA (15-39 years) cancers diagnosed at the integrated health care organizations of Kaiser Permanente (KP) Southern and Northern California during 2006-2020. A comparison cohort (n = 149,164) without cancer (matched 10:1 by age, sex, calendar year, and KP site) was included. Cumulative incidence (CMI) accounting for death as a competing risk was calculated. Poisson regression estimated the incidence rate ratio (IRR) of each condition in cancer survivors versus the matched cohort, adjusting for age, sex, and race/ethnicity.
resultsThe 5-year CMI was highest for thyroid (17.4%), respiratory (6.6%), cardiovascular (5.0%), and liver (4.8%) diseases. At 10 years, the CMI of any condition was 39% in survivors versus 26% in the matched cohort. Survivors had a 2-fold increased risk of being diagnosed with any medical condition (IRR, 2.0; 95% confidence interval [CI], 1.9-2.0) as well as two or more conditions (IRR, 2.3; 95% CI, 2.2-2.5). Risk was highest among survivors of hematologic cancers and those diagnosed with distant stage disease. Elevated risks were observed within all sociodemographic groups of this insured population.
conclusionAYAs with cancer had a higher risk of chronic medical conditions compared to those without cancer. Long-term surveillance, risk mitigation through lifestyle modifications and effective disease management are crucial to reduce premature mortality.
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