ArticlePsychological medicine2025
Executive function mediates prefrontal excitation-inhibition balance and emotion recognition in euthymic bipolar disorder.
Cheng Ying Wu, Chih-Yu Chang, Shyh-Yuh Wei, Hui Hua Chang, Ying Tsung Tsai, Tsung-Hua Lu, Ren-Yi Lin, Yen Kuang Yang, Po See Chen, Yu-Lien Huang and 1 more
Abstract read
In one paragraphArticle in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Cheng Ying WuDepartment of Psychiatry, https://ror.org/01b8kcc49National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chih-Yu ChangDepartment of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shyh-Yuh WeiDepartment of Psychiatry, https://ror.org/01b8kcc49National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0003-3704-2434 Hui Hua ChangInstitute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University, Tainan, Taiwan.
Ying Tsung TsaiDepartment of Psychiatry, https://ror.org/01b8kcc49National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-6824-8921 Tsung-Hua LuDepartment of Psychiatry, https://ror.org/01b8kcc49National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ren-Yi LinMind Research and Imaging Center, National Cheng Kung University, Tainan, Taiwan.
Yen Kuang YangDepartment of Psychiatry, https://ror.org/01b8kcc49National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Po See ChenDepartment of Psychiatry, https://ror.org/01b8kcc49National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yu-Lien HuangDepartment of Psychology, https://ror.org/059ryjv25Chung Shan Medical University, Taichung, Taiwan.
Huai-Hsuan TsengDepartment of Psychiatry, https://ror.org/01b8kcc49National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-5213-1585 Funding
Ministry of Science and Technology, Taiwan MOST 107-2314-B-006-082Ministry of Science and Technology, Taiwan MOST 107-2320-B-006-016Ministry of Science and Technology, Taiwan MOST 107-2628-B-006-005Ministry of Science and Technology, Taiwan MOST 108-2628-B-006-004Ministry of Science and Technology, Taiwan MOST 109-2628-B-006-004Ministry of Science and Technology, Taiwan MOST 110-2314-B-006-061-MY3Ministry of Science and Technology, Taiwan MOST 110-2320-B-006-022
6 · The paper itselfAbstract
backgroundEuthymic bipolar disorder (euBD) patients exhibit deficits in neurocognitive and social cognitive functioning compared to healthy controls (HCs). Our prior research has shown that the excitatory/inhibitory (
methodsSeventy-five HCs and 49 euBD individuals were recruited. Using the emotion recognition task, Diagnostic Analysis of Nonverbal Accuracy 2-Taiwan version (DANVA-2-TW) and cognitive flexibility task, Wisconsin Card Sorting Test (WCST), we assessed emotion recognition and prefrontal function. Proton magnetic resonance spectroscopy (
resultseuBD patients showed poorer emotion recognition (
conclusionThe BD patients demonstrate deficits in emotion recognition, linked to an altered E/I balance in the prefrontal cortex, and the cognitive flexibility, a key aspect of executive function, mediates the impact of the E/I ratio on emotion recognition accuracy in euBD patients.
Indexed as
Bipolar DisorderEmotionsExecutive FunctionPrefrontal CortexRecognition, PsychologyAdultFemaleGyrus CinguliHumansInhibition, PsychologicalMaleMiddle AgedNeuropsychological Tests1H-MRSbipolar disorderE/I imbalanceGABAergicglutamatergicsocial cognition
Identifiers
PMID41070707
PMCPMC12551578
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390