Evidence map›Paper›PMID 41070618›Full record

ArticleInternational journal of molecular medicine2025

Suppression of tumor growth by GMI, an edible fungal immunomodulatory protein, is associated with targeting GSK3β‑mediated proteasomal degradation of PD‑L1.

Wei-Jyun Hua, Li-Chen Huang, Zhi-Hu Lin, Yi-Ru Ciou, Kai-Fan Lin, Li-Lan Liao, Wei-Hung Hsu, Tung-Yi Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei-Jyun HuaInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C.
Li-Chen HuangInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C.
Zhi-Hu LinInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C.
Yi-Ru CiouInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C.
Kai-Fan LinInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C.
Li-Lan LiaoInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C.
Wei-Hung HsuInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C.
Tung-Yi LinInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells evade T cell responses by exploiting programmed death‑ligand 1 (PD‑L1) in the tumor microenvironment, and oncogenic epidermal growth factor receptor (EGFR) signaling stabilizes PD‑L1 expression.

Indexed as

B7-H1 AntigenFungal ProteinsGanodermaGlycogen Synthase Kinase 3 betaLung NeoplasmsProteasome Endopeptidase ComplexAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMiceMice, Inbred BALB CProteolysisSignal TransductionB7-H1 AntigenCD274 protein, humanFungal ProteinsGlycogen Synthase Kinase 3 betaProteasome Endopeptidase Complexantitumor immunityGMIlung cancerPD‑L1 degradationproteasomal pathway

Identifiers

PMID41070618
PMCPMC12530795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.