ArticleJournal of oral & facial pain and headache2025
Preclinical evaluation of dose-dependent effects of photobiomodulation therapy on persistent inflammation in the temporomandibular joint.
Article in Journal of oral & facial pain and headache, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLow-level laser therapy (LLLT) is a non-invasive, innovative approach for alleviating pain and improving function in temporomandibular joint (TMJ) disorders. This study aimed to compare the effect of three different doses of photobiomodulation (PBM) (2.5, 5 or 10 J/cm
methodsMale Wistar rats (n = 240) were submitted to a model of temporomandibular inflammation induced by induced by Complete Freund's Adjuvant (CFA) and treated with PBM on days 1, 3, 5, 7 and 10 post-CFA or saline (SAL) injection. Assessments included orofacial mechanical sensitivity through von Frey test, quantification of Evans blue plasma extravasation, myeloperoxidase activity analysis (MPO) and neutrophil/leukocyte infiltration in synovial fluid and TMJ tissues.
resultsRegarding the analgesic effect of LLLT, an inverted U-shaped curve was observed, as despite the effectiveness of all three tested doses, the 5 J/cm
conclusionsThis study highlights the dose-dependent efficacy of LLLT, with an intermediate dose (5 J/cm
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