ArticleJournal of the American Heart Association2025
Sex-Specific Cardiovascular Consequences of Long-Term High-Salt Diet in Mice.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
backgroundExcessive dietary salt intake is associated with elevated blood pressure and damage to organs including the heart, vasculature, and kidneys. Women are more prone to salt-sensitive hypertension, yet preclinical studies often focus on men.
methodsTo examine sex-specific responses to chronic salt loading, male and female C57Bl6/J mice were fed a high-salt diet (HSD; 8% NaCl) from 7 to 14 months of age. Subsets of HSD mice were switched to a normal diet after 28 weeks. Blood pressure was measured via tail-cuff plethysmography, and cardiac function assessed by magnetic resonance imaging. Vascular responses were analyzed by wire myography, and histological and molecular analyses were performed on heart, aorta, and kidney tissues.
resultsAfter 56 weeks, only HSD-fed females exhibited increased systolic blood pressure (
conclusionsChronic high salt intake leads to distinct sex-specific cardiovascular remodeling in mice. Importantly, diet reversal mitigates these effects, highlighting the potential of dietary interventions in salt-sensitive cardiovascular risk.
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