Observational studyTurk psikiyatri dergisi = Turkish journal of psychiatry2025
Association Between Sirtuin 1 (SIRT1) Gene Polymorphisms and Suicide Attempts in Schizophrenia: An Exploratory Study.
Observational study in Turk psikiyatri dergisi = Turkish journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Hippocampal miR-34a/SIRT1 and BDNF Responses Following Adolescent Stress: Differential Effects of Ketamine and Fluoxetine.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2026Article
- Peripheral Circular RNA Expression Levels in Schizophrenia and Schizoaffective Disorder: Associations with Clinical Characteristics and Behavioral Phenotypes.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2025Article
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3 authors.
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Abstract
objectiveSchizophrenia is a neuropsychiatric disorder with a high risk of suicide, arising from the interplay between genetic predisposition and environmental factors. The Sirtuin 1 (SIRT1) gene, an NAD⁺- dependent deacetylase, is involved in cellular stress response, apoptosis, and mitochondrial functions, as well as neuroprotection and circadian rhythm regulation. SIRT1 is thought to influence neurobiological mechanisms related to cognitive and affective regulation. This study aimed to investigate the association between specific SIRT1 gene polymorphisms and suicide attempts in patients with schizophrenia.
methodsThis cross-sectional, observational genetic association study included only a case group comprising 100 patients diagnosed with schizophrenia. Targeted sequencing of the SIRT1 gene, encompassing all coding exons and their exon-intron junctions, was performed. Based on minor allele frequency and technical quality criteria, 10 single nucleotide polymorphisms (SNPs) were selected for further analysis. Linkage disequilibrium (LD) assessment, haplotype structure, and genetic modeling were conducted using the SHEsis software platform.
resultsThe rs10997870 GG genotype (p=0.017) and the rs7896005 AA genotype (p=0.033) were associated with suicide attempts, whereas the rs2236318 A allele (p=0.015) and the rs41299232 GG genotype (p=0.027) were found to be protective. The C-T-A-G haplotype (p=0.005) was associated with an increased risk, while the G-A-G-T haplotype (p=0.032) showed a protective effect.
conclusionCertain polymorphisms and haplotypes within the SIRT1 gene may be associated with suicide risk among patients with schizophrenia. These findings point to the potential role of genetic profiling in identifying high-risk individuals. Further large-scale studies are warranted to increase the generalizability of the findings and to elucidate the underlying mechanisms in greater detail.
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