Evidence map›Paper›PMID 41070403›Full record

ReviewChembiochem : a European journal of chemical biology2025

Citrus Flavonoids for Cystic Fibrosis Treatment.

Mario Pagliaro, Caterina Di Sano, Claudia D'Anna, Giovanna Li Petri, Giuseppe Angellotti, Rosaria Ciriminna

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Citrus Flavonoids for Cystic Fibrosis Treatment.Chembiochem : a European journal of chemical biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mario PagliaroIstituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146, Palermo, Italy.ORCID https://orcid.org/0000-0002-5096-329X
Caterina Di SanoIstituto per la Farmacologia Traslazionale, CNR, via U. La Malfa 153, 90146, Palermo, Italy.ORCID https://orcid.org/0000-0003-3904-3465
Claudia D'AnnaIstituto per la Farmacologia Traslazionale, CNR, via U. La Malfa 153, 90146, Palermo, Italy.ORCID https://orcid.org/0000-0001-6673-1701
Giovanna Li PetriIstituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146, Palermo, Italy.ORCID https://orcid.org/0000-0001-6113-5978
Giuseppe AngellottiIstituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146, Palermo, Italy.ORCID https://orcid.org/0000-0001-9226-4748
Rosaria CiriminnaIstituto per lo Studio dei Materiali Nanostrutturati, CNR, via U. La Malfa 153, 90146, Palermo, Italy.ORCID https://orcid.org/0000-0001-6596-1572

Funding

European Union - NextGenerationEU (MICS) Extended Partnership (PNRR - Missione 4, Componente 2, Investimento 1.3 - D.D. 1551.11-10-2022, PE00000004) SAMOTHRACE (Sicilian Micro and Nano Technology Research and Innovation Center) Innovation Ecosystem (PNRR - Mission 4 Component 2 - Investment 1.5 (ECS00000022) - CUPB63C22000620005)Ministero dell'Università e della Ricerca Progetto "FutuRaw", Le materie prime del futuro da fonti non-critiche, residuali e rinnovabili, Fondo Ordinario Enti di Ricerca, 2022, CNR (CUP B53C23008390005)
6 · The paper itself

Abstract

Studies conducted since the late 1990s show substantial activity of selected citrus flavonoids as cystic fibrosis transmembrane conductance regulator (CFTR) membrane protein activators. Aimed at reinvigorating fundamental and applied research on citrus flavonoids for the treatment of mucoviscidosis, the thesis of this work is that aptly formulated citrus flavonoids hold significant potential for developing a multitarget treatment of cystic fibrosis combining in a single treatment antimicrobial, anti-inflammatory, CFTR-stimulating, and immunomodulatory properties, as required by a genetic disease eventually causing chronic lung inflammation and bacterial infection reinforcing each other.

Indexed as

CitrusCystic FibrosisFlavonoidsAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsCystic Fibrosis Transmembrane Conductance RegulatorHumansAnti-Bacterial AgentsAnti-Inflammatory AgentsCystic Fibrosis Transmembrane Conductance RegulatorFlavonoidsantibacterialanti‐inflammatoryCFTR stimulationcitrus flavonoidscystic fibrosis

Identifiers

PMID41070403
PMCPMC12582154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.