ArticleFrontiers in veterinary science2025
Identification of copy number variations through whole genome resequencing between Jiuyishan and Hyplus rabbits.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Copy number variations (CNVs), which include duplications and deletions of DNA segments, are significant structural variants that play crucial roles in the genetics of complex traits in livestock. High-throughput sequencing technologies enable the systematic identification of structural variants across genomes. However, CNV-based analyses of whole-genome sequencing data in rabbits remain largely unexplored. Herein, we characterized genome-wide CNVs of two rabbit breeds, Jiuyishan rabbit (JY) and Hyplus rabbit (HP), using whole-genome resequencing to elucidate their genetic characteristics and selection signatures. In total, 5,599 CNV regions (CNVRs) were identified between JY and HP, covering 0.98% of the reference genome. To identify selection signatures, we employed variance stabilizing transformation (Vst) values, selecting the top 1% of CNVRs with the highest Vst values, resulting in 56 CNVRs. These CNVRs harbored 27 genes. Functional analyses indicated that these genes were associated with important traits such as growth (
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