ArticleFrontiers in endocrinology2025
A pilot study evaluating differences in muscle tissue saturation and blood flow between older adults with and without sarcopenia.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03701867 (A Pilot Study to Explore Muscle Energy Metabolism and Metabolic Flexibility in Older Men and Women), which is not on this map. Not yet cited in PubMed.
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A Pilot Study to Explore Muscle Energy Metabolism and Metabolic Flexibility in Older Men and Women
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8 authors.
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Abstract
Introduction: To optimize skeletal muscle function, adequate oxygen transport and nutrient delivery to the muscle is needed. Decreased blood flow with aging may result in reduced nutritive flow to muscle, which may be compounded by those with less muscle mass. The purpose of this study was to examine differences in muscle oxygen utilization and muscle blood flow between non-sarcopenic and sarcopenic adults during pre- and post-prandial periods and during aerobic and anaerobic exercise. Methods: Ten older adults (mean±SD; age=72.4±4.9y; stature=167.5±7.6cm; body mass=71.6±12.2kg) were categorized as non-sarcopenic, and eight (age=82.9±11.4y; stature=165.7±4.5cm; body mass=70.3±8.0kg) were categorized as sarcopenic based on handgrip strength, body composition, and physical performance. Near-infrared spectroscopy (NIRS) was recorded pre-and-post consumption of a rapidly-digesting carbohydrate meal and during aerobic and anaerobic exercise. Deoxygenated hemoglobin (Hb)+myoglobin (Mb) (deoxyHb), Total Hb+Mb (THb) and muscle tissue oxygen saturation index (TSI) was measured using NIRS. Changes from baseline were calculated for deoxyHb and THb normalized to adipose tissue thickness (ΔdeoxyHb Results: Post-prandial, non-sarcopenic individuals had 224% greater ΔTHb Discussion: Sarcopenia demonstrated decreased oxidative capacity and blood flow detectable by NIRS, potentially contributing to metabolic dysfunction. While more research is needed, NIRS responses were distinct between sarcopenic and non-sarcopenic individuals post-prandial and during exercise. Nutrition and exercise interventions focusing on strategies to improve blood flow to promote muscle health are necessary to reduce sarcopenia and related-metabolic dysfunction progression with aging. Clinical trials registry number: NCT03701867, clinicaltrials.gov.
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