ArticlePakistan journal of medical sciences2025
Effects of ultrasound of different intensities plus neurotrophic factors on inflammatory markers and oxidative stress, and clinical efficacy in patients with diabetic peripheral neuropathic pain.
Article in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the efficacy of different ultrasound intensities combined with neurotrophic factors (NTFs) in diabetic peripheral neuropathic pain (DPNP) patients, focusing on pain relief, inflammation, and oxidative stress. Methodology: In this retrospective study, a total of 180 patients with DPNP admitted to Affiliated Hospital of Hebei University from October 2022 to December 2023 were randomized into control (gabapentin), low-dose (L: 0.5-1.0 W/cm²), and medium-dose (M: 1.0-1.75 W/cm²) ultrasound groups, all receiving 20 mg/day ganglioside for 5 weeks. Outcomes included Visual Analog Scale (VAS) scores, inflammatory markers (TNF-α, CRP, IL-6), and oxidative stress markers (SOD, GSH-Px, TAC, CAT, GR). Results: The L group showed higher overall response rates (88.33%) versus M (73.33%) and control (53.33%) (P=0.000). VAS scores decreased most in L group (P=0.00). TNF-α, CRP, and IL-6 levels reduced significantly in L/M groups versus control (P<0.05), with no intergroup differences (P>0.05). SOD, GSH-Px, TAC, and CAT levels improved most in L group (P=0.00). GR levels showed no significant difference among these groups (P = 0.88). Conclusion: Low-dose ultrasound combined with NTFs significantly alleviates DPNP pain, reduces inflammation, and enhances antioxidant capacity, demonstrating superior clinical efficacy.
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