ArticlePakistan journal of medical sciences2025
Correlation of clone size with clinical and lab presentation in Paroxysmal nocturnal hemoglobinuria (PNH): A single center experience.
Article in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Unprovoked Venous Thromboembolism in a Patient with a Small PNH Clone: A Therapeutic Dilemma.Journal of Brown hospital medicine · 2026Article
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5 authors.
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Abstract
Objective: To determine the correlation between clone size in Paroxysmal nocturnal hemoglobinuria and clinical presentation. Methodology: A prospective study was conducted in Armed Forces Bone Marrow Transplant Center (AFBMTC), between 2021-2024. PNH testing was done by multiparametric flow cytometry using fluorescently labeled Alexa-488. PNH clone was labelled as large (>50%) or small (<30%) based on ASH education program 2021. Clone size was correlated with type of presentation of PNH and hemolysis. Statistical analyses were performed using SPSS v 25.0. Results: Out of 324 samples, 96 (29.6 %) were found to have PNH clone by FLAER. Among 75 evaluable cases, 55 (71.2%) were diagnosed as classical hemolytic PNH(CPNH), 16 (21.3%) as PNH in context of marrow failure, 3 (4.2%) as aplastic anemia transformed into PNH, 1 (1.4%) case of MDS with PNH clone. Mean age of patients was 30.97 + 10.56 years. 60 (82.2%) patients were male while 15 (17.3%) were female. On granulocytes, large clone (>50%) was found in 81.3% cases and small clone (<30%) in 18.6% cases. Similarly, 73.3% cases had a large clone on monocytes while 26.6% had a small clone. However, most cases (62.6%) had a smaller RBC clone size. Granulocytic and monocytic clone sizes were significantly associated with Hb and platelet count (p- value <0.05). However, RBC clone size did not show any significant association with the blood counts. Similarly, no significant correlation could be found between markers of hemolysis/ thrombosis. Conclusion: Size of PNH clone impacts the clinical presentation with large PNH clones typically seen in CPNH.
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