Giant ischial osteochondroma causing ischiofemoral impingement and sciatic nerve compression in a pediatric patient with Albright's hereditary osteodystrophy.

Travis Jebackumar, Ryan Johnson, Avery Schroeder, Claudio Silveri, Jan Lesensky, Ana C Belzarena

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Article in Radiology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Travis JebackumarThe University of South Carolina School of Medicine, Columbia, SC, USA.

Ryan JohnsonMeharry Medical College, Nashville, TN, USA.

Avery SchroederOrthopaedic Surgery Department, University of Missouri, Columbia, MO, USA.

Claudio SilveriUnidad de Patología Oncológica Musculo Esquelética, Instituto Nacional de Ortopedia y Traumatología, Montevideo, Uruguay.

Jan LesenskyDepartment of Orthopedics, First Medical Faculty, Charles University, University Hospital Na Bulovce, Prague, Czech Republic.

Ana C BelzarenaOrthopaedic Surgery Department, University of Missouri, Columbia, MO, USA.

Funding

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6 · The paper itself

Abstract

An 8-year-old female with Albright's hereditary osteodystrophy (AHO) presented with severe right buttock pain, difficulty walking, and a palpable mass in the right ischiofemoral region. Imaging studies demonstrated a large, ossified lesion compressing the sciatic nerve. Surgical resection of the mass resulted in complete resolution of symptoms and restoration of normal gait and function. AHO is a rare genetic disorder caused by mutations in the GNAS1 gene and is characterized by musculoskeletal abnormalities, including a predisposition to subcutaneous ossifications. While osteochondromas are typically asymptomatic, they can cause significant clinical symptoms when they enlarge or impinge on adjacent neurovascular structures. This case illustrates the rare co-occurrence of AHO and a symptomatic giant osteochondroma, underscoring the importance of early recognition and surgical intervention to prevent functional impairment due to neurovascular compression.

Indexed as

Albright’s hereditary osteodystrophyGiant osteochondromaNerve compression

Identifiers

PMID41070289

DOI10.1016/j.radcr.2025.08.075

PMCPMC12506491

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