ArticleLife metabolism2025
Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation.
Article in Life metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- AMPK-mediated modulation of JAK2/STAT3 signaling in asthma: a promising target for controlling airway inflammation and remodeling.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
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15 authors.
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Abstract
Energy stress triggers the activation of AMP-activated protein kinase (AMPK) via phosphorylation mediated by liver kinase B1 (LKB1). A pivotal step during this process is the translocation of protein kinase C zeta (PKCζ) to the nucleus, where it facilitates the phosphorylation and subsequent nuclear export of LKB1 to the cytosol. However, the mechanism(s) by which PKCζ translocates to the nucleus remains elusive. Here we demonstrate that energy stress, including glucose starvation or metformin treatment, elevates cellular reactive oxygen species (ROS) that promotes PKCζ nuclear import to promote LKB1 cytoplasmic translocation and subsequent AMPK activation both
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