ArticleCurrent research in microbial sciences2025
New Andes virus isolate haplotype obtained during prospective close contacts follow-up of an Hantavirus cardiopulmonary syndrome fatal case, Chile.
Article in Current research in microbial sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Habitat-Mediated Spillover Risk of Andes Hantavirus inViruses · 2026Article
- Andes hantavirus in South America: Emerging epidemiological trends, regional challenges, and lessons beyond the MV Hondius outbreak.New microbes and new infections · 2026Article
- Hantavirus Cluster Linked to Cruise Ship Travel: A Comprehensive Review of a Looming Global Public Health Concern.Cureus · 2026Review
- Article
- Andes virus outbreak linked to expedition cruise ship travel, multi-country investigation and response, April to June 2026.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Andes virus (ANDV) is a zoonotic orthohantavirus that causes hantavirus cardiopulmonary syndrome. Transmission occurs mainly through contact with infected rodent excreta and, less frequently, between humans. Viral isolation from human samples is rare; in Chile, only one strain (CHI-7913, 2002) has been reported. The limited number of isolates reflects the challenge of obtaining samples during early viremia before antibodies appear, and maintaining long-term production of infectious particles in culture. We investigated an asymptomatic case from a family cluster, sampled during early infection. The absence of anti-ANDV antibodies in sera was confirmed by ELISA. Blood fractions were used to infect Vero E6 cells for six weeks, with infectivity monitored by RT-qPCR and Immunofluorescence. We obtained a replication-stable isolate from the buffy-coat fraction, achieving high viral loads at early passages. Whole-genome sequencing revealed a novel haplotype with mutations that reverted during non-human cell culture adaptation. This isolate, designated CHI-Hu13724, represents a new human-derived ANDV strain first reported in over two decades in Chile. It provides a valuable tool to study viral replication, infectivity, and pathogenicity.
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Registered trials
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