Evidence map›Paper›PMID 41070167›Full record

ArticleSouthern African journal of infectious diseases2025

Impact of chlorhexidine and emollient cleansing on bloodstream infections in a Neonatal ICU.

Pervashni Padayachee, Fathima Naby, Partson Tinarwo, Sumayya Haffejee, Trudy Martin, Vikash Deonundhan, Yashika Umichand, Moherndran Archary

Abstract read
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In one paragraph

Article in Southern African journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pervashni PadayacheeDepartment of Paediatrics and Child Health, Faculty of Health Sciences, University of Kwazulu-Natal, Nelson R. Mandela School of Medicine, Durban, South Africa.ORCID https://orcid.org/0009-0000-1394-0251
Fathima NabyDepartment of Paediatrics and Child Health, Faculty of Health Sciences, University of Kwazulu-Natal, Nelson R. Mandela School of Medicine, Durban, South Africa.ORCID https://orcid.org/0000-0002-3537-2707
Partson TinarwoDepartment of Biostatistics, Faculty of Health Sciences, University of KwaZulu-Natal, Nelson R. Mandela School of Medicine, Durban, South Africa.ORCID https://orcid.org/0000-0003-4528-0635
Sumayya HaffejeeDepartment of Medical Microbiology, Faculty of Health Sciences, University of KwaZulu-Natal, Nelson R. Mandela School of Medicine, Durban, South Africa.ORCID https://orcid.org/0009-0008-1677-2255
Trudy MartinDepartment of Paediatrics and Child Health, Faculty of Health Sciences, University of Kwazulu-Natal, Nelson R. Mandela School of Medicine, Durban, South Africa.ORCID https://orcid.org/0009-0004-0903-5581
Vikash DeonundhanDiscipline of Pharmaceutical Sciences, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.ORCID https://orcid.org/0009-0001-1307-5867
Yashika UmichandDepartment of Paediatrics and Child Health, Pietermaritzburg Metropolitan Hospital Complex, Pietermaritzburg, South Africa.ORCID https://orcid.org/0009-0005-4667-4566
Moherndran ArcharyDepartment of Paediatrics and Child Health, Faculty of Health Sciences, University of Kwazulu-Natal, Nelson R. Mandela School of Medicine, Durban, South Africa.ORCID https://orcid.org/0000-0003-3082-9234

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Among hospital-born babies, infections account for 4% - 56% of deaths in the neonatal period, with bloodstream infections being up to 20 times more frequent in low- and middle-income countries (LMICs). The cleansing of infants with chlorhexidine (without emollient) has been the standard of care in Grey's Hospital Neonatal Intensive Care Unit (NICU) for over a decade. Objectives: This study evaluated the impact of adding an emollient to chlorhexidine on the prevalence of microbiologically confirmed infections. Method: A retrospective observational cohort study of all microbiologically confirmed bloodstream infections in the neonatal unit before (01 June 2022 to 30 November 2022) and after (01 December 2022 to 31 May 2023) the implementation of the quality improvement project was conducted. The rates of microbiologically confirmed infections were compared between the two periods. Results: There was a total number of 2741 positive blood cultures over the study period with a significant reduction in positive cultures in the intervention group (46.1% vs. 27%, Conclusion: Further research evaluating the response in larger study populations is needed. Contribution: Although there was no significant reduction in sepsis-associated mortality, cleansing infants using chlorhexidine with an emollient may reduce bloodstream infections in this vulnerable population in LMICs.

Indexed as

blood stream infectionschlorhexidineemollientmortalityneonatalsepsis

Identifiers

PMID41070167
PMCPMC12506584

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.