Kimura Disease: Retrospective Analysis of 53 Cases and Three Mepolizumab-Responsive Cases.

Background: Kimura disease (KD) is a rare, chronic lymphoproliferative disorder, which is believed to be driven by a Th2 immune response, though its exact pathogenesis remains unclear. Despite various treatment approaches, no standardized therapy has been established. This study investigated the clinical features of 53 KD patients and evaluated the therapeutic potential of mepolizumab in three cases. Methods: A retrospective age-stratified analysis was performed on 53 patients diagnosed with KD at two tertiary medical centers in China, covering the period from January 2014 to December 2024. We also provided an in-depth case series of three patients who received mepolizumab treatment. Results: This study included 53 KD patients, predominantly male (88.7%) with a mean age of 41 years. The median time from symptom onset to diagnosis was 24 months, and the median lesion diameter was 3.0 cm. Pruritus was present in 52.8% of patients, with frequency increasing with age (P=0.015). Coexisting conditions included IgG4-related disease (11.3%), asthma (9.4%), and thrombotic events (9.4%). Lesions were bilateral in 66.0% and primarily located in the head and neck region (83.0%). Average eosinophil count was 2.09 × 10 Conclusion: This study provided a comprehensive summary and age-stratified analysis of the clinical characteristics of KD, providing valuable insights into its pathophysiology and potential overlapping mechanisms. Additionally, the study presents clinical cases of three patients treated with mepolizumab, highlighting its potential as a promising therapeutic option for the management of KD.