Evidence map›Paper›PMID 41070112›Full record

ArticleBrain, behavior, & immunity - health2025

Inflammatory predictors of Post-COVID fatigue.

A Nuber-Champier, G Breville, P Voruz, I Jacot de Alcântara, P H Lalive, G Allali, L Benzakour, K-O Lövblad, O Braillard, M Nehme and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

A Nuber-ChampierClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Geneva, Switzerland.
G BrevilleNeurology Division, Geneva University Hospitals, Switzerland.
P VoruzClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Geneva, Switzerland.
I Jacot de AlcântaraClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Geneva, Switzerland.
P H LaliveNeurology Division, Geneva University Hospitals, Switzerland.
G AllaliLeenaards Memory Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
L BenzakourFaculty of Medicine, University of Geneva, Switzerland.
K-O LövbladFaculty of Medicine, University of Geneva, Switzerland.
O BraillardDivision and Department of Primary Care, Geneva University Hospitals, Switzerland.
M NehmeDivision and Department of Primary Care, Geneva University Hospitals, Switzerland.
M CoenDivision of General Internal Medicine, Department of Medicine, Geneva University Hospitals and Geneva University, Switzerland.
J SerratriceDivision of General Internal Medicine, Department of Medicine, Geneva University Hospitals and Geneva University, Switzerland.
J-L RenyDivision of General Internal Medicine, Department of Medicine, Geneva University Hospitals and Geneva University, Switzerland.
J PuginFaculty of Medicine, University of Geneva, Switzerland.
I GuessousFaculty of Medicine, University of Geneva, Switzerland.
B N LandisFaculty of Medicine, University of Geneva, Switzerland.
A CioncaÉcole Polytechnique Fédérale de Lausanne (EPFL), School of Engineering, Neuro-X Institute, Lausanne, Switzerland.
F AssalNeurology Division, Geneva University Hospitals, Switzerland.
J A PéronClinical and Experimental Neuropsychology Laboratory, Faculty of Psychology, University of Geneva, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biological mechanisms underlying objective and subjective fatigue in post-COVID syndrome remain unclear. This study investigates whether immune responses during the acute phase of SARS-CoV-2 infection predict fatigue dimensions 6-9 months post-infection. We analyzed serum immune markers from 54 hospitalized patients (mean age: 58.69 ± 10.90 yrs; female: 31 %) and assessed their association with chronic fatigue using general linear mixed models. Elevated levels of IL-1RA, IFNγ, TNFα, and monocyte percentage during acute infection predicted increased physical and total fatigue. Additionally, higher TNFα levels (r = -0.40,

Indexed as

COVID-19FatigueImmunityImmunologyInflammationLong COVIDSARS-CoV-2

Identifiers

PMID41070112
PMCPMC12506529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.