ArticleFrontiers in cardiovascular medicine2025
Pericoronary adipose tissue inflammation mediates the atherogenic effects of lipids on multivessel coronary artery disease: a CCTA-based radiomics analysis.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Review
- Mediation of stenosis-induced ischemia by proximal peri-coronary adipose tissue: A cross-sectional study.Medicine · 2026Article
- Association of pericoronary fat attenuation index and insulin resistance for the risk of cardiometabolic multimorbidity: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Oxidative dyslipidemia in early pregnancy: integrating atherogenic index of plasma (AIP) and uric acid (UA) to refine preeclampsia risk stratification.Frontiers in pharmacology · 2026Article
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5 authors.
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Abstract
Objective: The atherogenic index of plasma (AIP) is a robust predictor of cardiovascular risk. However, its mechanism of action in the severity of coronary artery disease (CAD) remains unknown. We investigated whether pericoronary adipose tissue inflammation [assessed using the fat attenuation index (FAI)] mediates the association between AIP and CAD in middle-aged and older adults. Methods: A total of 450 patients who underwent coronary computed tomography angiography at Yan'an University Affiliated Hospital (2022-2024) were enrolled in this study. Coronary atherosclerotic disease (CAD) severity was defined as multivessel CAD (MVCAD; ≥50% stenosis in ≥2 arteries). The fat attenuation index (FAI) was measured around the right coronary artery (RCA-FAI) using a standardized radiomics protocol. Logistic regression and mediation analyses (PROCESS macro, 1,000 bootstrap samples) were used to quantify these associations. Results: The atherogenic index of plasma (AIP) independently predicted MVCAD (OR = 2.35, 95% CI: 1.96-5.10, Conclusion: This is the first study to demonstrate that coronary arterial inflammation (RCA-FAI) partially mediates the atherogenic effects of AIP on MVCAD, suggesting a dual pathway of lipid-driven inflammation and metabolic dysregulation. Our findings highlight RCA-FAI as a promising imaging biomarker for CAD risk stratification, irrespective of glucose metabolism status.
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