ArticleFrontiers in medicine2025
Diagnostic efficacy of magnifying endoscopy with blue laser imaging for laryngopharyngeal reflux.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Objectives: We aimed to analyze the utility of magnifying endoscopy with blue laser imaging (ME-BLI) in diagnosing laryngopharyngeal reflux (LPR). Methods: The study enrolled 106 patients based on LPR-related symptoms. Using the reflux symptom index (RSI) and reflux finding score (RFS) scales as the clinical reference standard, the study cohort comprised 68 patients with LPR (RSI >13 and/or RFS >7) and 38 controls (RSI ≤13 and RFS ≤7). All participants underwent upper gastrointestinal endoscopy with ME-BLI. The patients were classified into Grades 1-4 based on the pharyngolaryngeal appearance under ME-BLI and the visibility and characteristics of intraepithelial papillary capillary loops (IPCLs) in the pharyngolaryngeal mucosa. Grades 3 and 4 were defined as LPR-positive. The diagnostic performance of ME-BLI for LPR was compared to the RSI/RFS criteria. Results: Compared with the RSI/RFS clinical reference standard, ME-BLI demonstrated a sensitivity of 89.71% (95% CI: 81.54-94.44%), a specificity of 73.68% (95% CI: 59.72-84.03%), a positive predictive value of 85.92% (95% CI: 76.34-92.04%), and a negative predictive value of 80.00% (95% CI: 64.06-90.04%) for LPR diagnosis. It also showed good consistency with RSI/RFS diagnosis (Kappa = 0.65, 95% CI: 0.52-0.78, Conclusion: LPR has characteristic pharyngeal manifestations. ME-BLI could potentially improve LPR diagnostic accuracy; however, further validation is required.
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