ArticleFrontiers in medicine2025
Application of a new coaxial bipolar electrode for the treatment of vertebral metastases: a pilot study in an ovine model.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Custom bipolar electrode for bleomycin-based electrochemotherapy in patient-derived uveal melanomaFrontiers in cell and developmental biology · 2026Article
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Authors and funding
16 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Introduction: Spinal metastases account for approximately 90% of masses detected through spinal imaging. Therefore, it is imperative to advance therapies. Electroporation modifies the permeability of cancer cell membranes using electric energy, increasing the local uptake of chemotherapeutics and promoting local tumor control. The aim of this study was to evaluate the safety of delivering electrical pulses that induce tissue ablation using novel coaxial bipolar electrodes in healthy bone and clinically relevant structures in an ovine model. Methods: Electroporation was performed on sheep vertebral bodies (L2-L4) applying an electric field intensity sufficient to deliver at least 3,500 J/Kg, absorbed energy previously shown to be effective in ablating bone tissue. The study also examined the impact on surrounding sensitive structures, such as peripheral nerves and the spinal cord. Effectiveness and safety assessment was performed by clinical evaluation, histological analysis and numerical simulation. Results: The results showed that the ablation induced by electroporation was clearly visible 7 days after treatment. This was confirmed histologically by the absence of osteoblasts, the complete inhibition of bone apposition, the presence of pyknotic osteocytes and the empty lacunae. The absence of tetracycline fluorescence further confirmed the absence of bone tissue growth in the ablated area. Histomorphometric analysis showed a significant difference ( Discussion: In agreement with these findings, temperature estimation based on computational simulation showed negligible increase in the spinal cord at the level of treated vertebra. Utilizing coaxial bipolar electrodes within the vertebral body through a transpedicular approach could offer a safe and minimally invasive procedure to treat spinal tumors and metastases, regardless of lesion size, while safeguarding critical neural structures.
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