Evidence map›Paper›PMID 41070043›Full record

ArticleInternational journal of nanomedicine2025

Two-Dimensional Magnesium Phosphate Nanosheets Promote Antibacterial Effects and Wound Closure.

Salma Younes, Salma M S Ahmad, Pannawich Thirabowonkitphithan, Shaden H Abunasser, Nouran Zein, Amir Elhadad, Asada Leelahavanichkul, Wanida Laiwattanapaisal, Awni Al-Otoom, Khaled A Mahmoud and 2 more

Abstract read
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In one paragraph

Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Salma YounesDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Salma M S AhmadDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Pannawich ThirabowonkitphithanDepartment of Biomedical Science, Faculty of Health and Society, Malmö University, Malmö, 20506, Sweden.
Shaden H AbunasserDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.ORCID 0000-0003-3820-7157
Nouran ZeinDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Amir ElhadadCollege of Dental Medicine, Qatar University, Doha, 2713, Qatar.
Asada LeelahavanichkulTranslational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Chulalongkorn, Bangkok, 10330, Thailand.ORCID 0000-0002-8331-021X
Wanida LaiwattanapaisalCentre of Excellence for Biosensors and Bioengineering (CEBB), Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Chulalongkor, Bangkok, 10330, Thailand.
Awni Al-OtoomChemical Engineering Department, Jordan University of Science and Technology, Irbid, 22110, Jordan.ORCID 0000-0003-1246-4067
Khaled A MahmoudQatar Environment and Energy Research Institute (QEERI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, 2713, Qatar.
Faleh TamimiCollege of Dental Medicine, Qatar University, Doha, 2713, Qatar.ORCID 0000-0001-9252-1038
Gheyath K NasrallahDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: NeoPhylaxis is a patented two-dimensional (2D) magnesium phosphate (MgP) hydrogel, initially approved in 2023 for dental applications such as implant decontamination, it has demonstrated strong safety and efficacy. This study explores its repurposing for antimicrobial and wound healing applications. Aim: To synthesize, characterize, and investigate the antibacterial properties, biocompatibility, and wound-healing potential of MgP hydrogel. Methods: The MgP hydrogel was synthesized via controlled crystallization of a sodium magnesium-phosphate system. Its structural and compositional properties were characterized using Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDX). Antibacterial efficacy was evaluated in vitro, while biocompatibility and wound healing efficacy were assessed in vivo using BALB/c mouse model. Mechanistic insights into the hydrogel's antibacterial properties were further investigated via SEM and TEM. Results: MgP hydrogels exhibited a dose-dependent antibacterial effect, reducing Conclusion: These findings highlight the potential of 2D MgP nanosheets as a multifunctional therapeutic agent for antimicrobial and wound healing applications.

Indexed as

Anti-Bacterial AgentsMagnesium CompoundsNanostructuresPhosphatesWound HealingAnimalsEscherichia coliFemaleHumansHydrogelsMiceMice, Inbred BALB CMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsHydrogelsMagnesium Compoundsmagnesium phosphatePhosphatesantibacterialbiocompatibilityinorganic hydrogelnanomaterialstwo-dimensional (2D)wound dressings

Identifiers

PMID41070043
PMCPMC12506775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.