ArticleJournal of advanced periodontology & implant dentistry2025
A pilot study and histological examination of xenograft and autogenous bone combinations with i-PRF in guided bone regeneration.
Article in Journal of advanced periodontology & implant dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Pilot Case Series of Lateral Ridge Augmentation Using a Collagenated Porcine-Derived Xenograft: Clinical, Histological, and Remodeling Outcomes.Journal of clinical medicine · 2026Article
- Bone Substitutes in Alveolar Ridge Augmentation: A Narrative Literature Review.Journal of functional biomaterials · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study evaluated the impact of different regenerative biomaterial combinations on bone quality and implant stability in guided bone regeneration (GBR). Methods: A pilot study was conducted from September 2020 to October 2023 to compare the quality of bone regeneration and implant stability following GBR using three composite graft combinations. Forty-seven patients participated in the study in three experimental groups: group A (deproteinized cancellous bovine bone [xenograft] with injectable platelet-rich fibrin [i-PRF]), group B (xenograft with autogenous bone graft in a 2:1 ratio with i-PRF), and group C (xenograft with autogenous bone graft in a 1:1 ratio with i-PRF). The implant stability quotient (ISQ) was measured at the time of implant placement. Crestal bone biopsy procedures were performed. Results: The study found that group C, using a 1:1 ratio of xenograft and autogenous graft with i-PRF, achieved the highest new bone formation (65.83%) and demonstrated moderately high vascularization and osteoclastic activity, indicative of good remodeling potential. ISQ measurements for all groups indicated good primary stability of implants, ranging from 55 to 65 at the time of placement. Conclusion: Combining xenograft with autogenous graft in a 1:1 ratio, along with i-PRF, yielded optimal outcomes for new bone formation in GBR procedures. However, further research is needed to address the limitations associated with i-PRF, such as lack of rigidity and faster degradation, to enhance its application in GBR procedures.
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