ReviewDEN open2026
Is Single-Session Peroral Endoscopic Myotomy With Fundoplication Safe and Effective in Achalasia? A Systematic Review and Meta-Analysis.
Review in DEN open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Peroral endoscopic myotomy (POEM) is a minimally invasive treatment for achalasia but is often associated with gastroesophageal reflux disease (GERD). Adding fundoplication (POEM+F) may reduce reflux while maintaining the benefits of myotomy. This systematic review and meta-analysis evaluate the efficacy and safety of POEM+F in achalasia patients. Methods: A comprehensive search of electronic databases and conference proceedings was conducted through November 2024 to identify studies on POEM+F. Pooled proportions were calculated using both fixed effects models. Heterogeneity was assessed via Cochran's Q test. Primary outcomes included technical success, Eckardt score improvement, and post-procedure esophagitis. Secondary outcomes included procedure time, adverse events, wrap integrity, and hospital stay. Results: Nine studies with 202 patients were included. The pooled technical success rate was 94.80% (95% confidence interval [CI]: 91.37-97.40). Mean total procedure time was 110.51 min, with 52.04 min for fundoplication. Eckardt scores improved from 8.30 (95% CI: 6.83-9.76) pre-operatively to 1.08 (95% CI: 0.33-2.50) post-operatively. Post-procedure, 11.52% (95% CI: 6.10-18.38) had abnormal acid exposure and 20.65% (95% CI: 14.47-27.61) developed esophagitis. An intact wrap was seen in 75.69% (95% CI: 58.55-89.40) on follow-up endoscopy. Mean hospital stay was 2.27 days (95% CI: 1.09-3.45). Conclusions: POEM with fundoplication is a safe and effective treatment for achalasia, offering high technical success, symptom relief, and a low incidence of GERD.
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Registered trials
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