ArticleInternational journal of women's health2025
Risk Factors for Umbilical Artery Thrombosis in Pregnant Women: A Retrospective Study.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Umbilical artery thrombosis (UAT) is a rare but potentially life-threatening complication in pregnancy. It shares ultrasonographic similarities with isolated single umbilical artery (iSUA), a relatively common condition with more favorable outcomes, highlighting the need for reliable differential markers. This study was performed to identify the risk factors for UAT in pregnant women. Also, we compared maternal and neonatal outcomes between UAT, iSUA, and normal controls with three umbilical vessels (NC). Patients and Methods: This retrospective study was conducted at the Women's Hospital, Zhejiang University School of Medicine. A total of 195 participants were included between January 1, 2020, and December 31, 2024, including 65 of UAT, 65 of iSUA, and 65 of NC. The baseline information, laboratory data and relevant perinatal outcomes of all participants were collected and analyzed. Logistic regression models were employed to evaluate the association between antepartum findings and UAT in pregnant women. Results: Compared with the iSUA group, the UAT group showed higher rates of abnormal fetal movement ( Conclusion: This study identifies distinct clinical, laboratory data, and sonographic markers that effectively differentiate UAT from iSUA, with abnormal fetal movement and FHR patterns, prolonged APTT, and umbilical cord hypercoiling as prominent risk factors for UAT.
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