ArticleFrontiers in aging neuroscience2025
Regional high iron deposition is linked with cognitive impairments in peritoneal dialysis: a quantitative susceptibility mapping study.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Peritoneal dialysis (PD) patients demonstrate distinct iron homeostasis imbalances. However, the relationship between brain iron and cognitive impairment in this population remains poorly elucidated. Methods: This study enrolled 52 PD patients and 49 healthy controls (HCs). Quantitative susceptibility mapping (QSM) was employed to quantify cerebral iron deposition. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and a comprehensive neuropsychological test battery. Dose-response relationships between iron metabolism parameters and cognitive performance were analyzed using generalized additive models (GAMs). Results: PD patients exhibited significantly higher iron deposition in the left amygdala and right putamen compared to HCs. Serum ferritin (SF) demonstrated an approximately inverted U-shaped relationship with MoCA scores, with an inflection point at 258.4 μg/L ( Conclusion: In peritoneal dialysis patients, abnormal cerebral iron deposition predominantly localizes to limbic-basal ganglia regions. Iron accumulation in the left amygdala may specifically mediate the development of multi-domain cognitive impairment. QSM represents a sensitive technique for early detection of pathological iron accumulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.