ArticleCureus2025
Comparison of Broth Disk Elution and Broth Microdilution Methods for Colistin Susceptibility Testing in Carbapenem-Resistant Enterobacteriaceae and Pseudomonas aeruginosa.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Beyond the tumor: cluster of difficult-to-treat (DTR) Klebsiella pneumoniae infection in cancer patients-healthcare-associated outbreak investigations.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increasing prevalence of carbapenem-resistant MATERIALS AND
methodsThis cross-sectional study was conducted over 18 months (December 2022 to June 2024) at a tertiary care microbiology laboratory in India. A total of 120 non-duplicate CRE and CRPA isolates from clinical specimens were randomly selected and tested for colistin susceptibility using both BMD and CBDE methods. MIC interpretations were based on CLSI 2024 guidelines. Categorical agreement (CA), essential agreement (EA), and error rates were analyzed as per CLSI 2015 recommendations.
resultsOut of 120 carbapenem-resistant isolates included in the study, 92 (76.67%) were CRE and 28 (23.33%) were CRPA. Colistin resistance was detected in six (5%) and four (3.33%) isolates by BMD and CBDE, respectively. CBDE showed a CA of 98.3% (95% confidence Interval: 94.1%-99.8%) and EA of 100% when compared to BMD, with only two minor errors (1.6%) and no major or very major errors.
conclusionCBDE demonstrated high categorical agreement with BMD and minimal error and offers a simple, cost-effective alternative for routine colistin susceptibility testing, especially in low-resource settings where BMD is not feasible.
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