Evidence map›Paper›PMID 41069858›Full record

ReviewiScience2025

Application of biomaterials in vascularization of cardiac organoids.

Jun Liu, Yaxing Feng, Peng Qu, Yunbo Luo, Jiao Shi, Cui Ma, Qi Liang, Long Zhao, Gang Li, Bo Yang and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jun LiuDepartment of Radiotherapy, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Yaxing FengCore Laboratory, School of Medicine, Sichuan Provincial People's Hospital Affiliated to University of Electronic Science and Technology of China, Chengdu 610072, China.
Peng QuInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Yunbo LuoDepartment of Breast Surgery, Plastic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Jiao ShiInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Cui MaDepartment of Mathematics, Army Medical University, Chongqing 400038, China.
Qi LiangDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, School of Laboratory Medicine, Translational Medicine Research Center, North Sichuan Medical College, Nanchong 637007, Sichuan, China.
Long ZhaoDepartment of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
Gang LiInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Bo YangDepartment of Radiotherapy, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Panke ChengInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac organoids (COs) are platforms for disease modeling and regenerative medicine, yet inadequate vascularization still limits their function and longevity. This review examines how biomaterial properties-porosity, elasticity, surface chemistry, and bioactivity-regulate endothelial cell behavior and vascular network formation, thereby shaping progress in organoid vascularization. We survey natural, synthetic, and composite systems (e.g., collagen, fibrin, polyethylene glycol [PEG] hydrogels, and poly(ε-caprolactone) [PCL] scaffolds) used to promote vascularization. We also summarize fabrication strategies to improve perfusion, including micro/nanopatterning, scaffold design, and delivery of pro-angiogenic factors, and we outline technical routes for spatially patterned vasculature such as three-dimensional (3D) bioprinting and microfluidics. Ongoing challenges include degradation mismatch and incomplete integration. Future work should emphasize stimuli-responsive and bioactive materials, as well as standardized, scalable scaffold platforms, to strengthen reproducibility and translational efficiency. These directions will help optimize the vascular microenvironment of organoids, enhance functional maturation, and broaden applications in disease modeling, drug evaluation, and regenerative repair.

Indexed as

Biological sciencesMaterials science

Identifiers

PMID41069858
PMCPMC12506531

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.