Evidence map›Paper›PMID 41069851›Full record

ArticleiScience2025

Cardiac mural cells are rate-limiting for coronary vascularization after heart injury.

Zhengkai Lu, Jian Zhou, Min Ye, Jufeng Meng, Teng Feng, Zhen Jiang, Wenxuan Dai, Defang Deng, Lei Yan, Yuanxin Wei and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zhengkai LuState Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Science and Technology, Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Jian ZhouDepartment of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Min YeSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Jufeng MengSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Teng FengSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Zhen JiangSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Wenxuan DaiDepartment of Cardiothoracic Surgery, Congenital Heart Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Defang DengSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Lei YanSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Yuanxin WeiSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Wen ZhangSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Jialei ZhengSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Yutao FuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Tongji Hospital affiliated to Tongji University, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Chao-Po LinSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Huiwen ChenDepartment of Cardiothoracic Surgery, Congenital Heart Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Guocheng ShiDepartment of Cardiothoracic Surgery, Congenital Heart Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Hui ZhangSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Juan TangState Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Science and Technology, Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited angiogenic potential of coronary vascular endothelial cells (cVECs) poses a significant barrier to effective therapeutic revascularization after myocardial infarction (MI). However, the underlying mechanisms of restricted vascularization post-MI remain unclear. Here, we demonstrate that both reduced density and limited proliferation of mural cells result in inadequate mural cell coverage of coronary vessels, consequently impeding coronary vascularization within the MI heart. Our findings reveal that the cell cycle inhibitor phosphatase and tensin homolog (PTEN) is expressed in mural cells from both sham-operated and MI hearts. Conditional

Indexed as

Cardiovascular medicineCell biology

Identifiers

PMID41069851
PMCPMC12506467

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.