Evidence map›Paper›PMID 41069767›Full record

ArticleFrontiers in cellular neuroscience2025

Sex-specific interneuron vulnerability after traumatic brain injury correlates with neurotrophic signaling and chloride homeostasis, independent of behavioral and network outcomes.

Amandine Consumi, Cécile Marcourt, Tayam Tnaimou, Jérôme Laurin, Michael K E Schäfer, Christophe Pellegrino, Claudio Rivera

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amandine ConsumiAix Marseille Université, INSERM, INMED, Marseille, France.
Cécile MarcourtAix Marseille Université, INSERM, INMED, Marseille, France.
Tayam TnaimouAix Marseille Université, INSERM, INMED, Marseille, France.
Jérôme LaurinAix Marseille Université, INSERM, INMED, Marseille, France.
Michael K E SchäferDepartment of Anaesthesiology, University Medical Center Mainz, Mainz, Germany.
Christophe PellegrinoAix Marseille Université, INSERM, INMED, Marseille, France.
Claudio RiveraAix Marseille Université, INSERM, INMED, Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) leads to persistent cognitive and emotional impairments, and growing evidence suggests that sex influences vulnerability through differences in neurotrophic signaling and chloride homeostasis. To investigate these mechanisms, we induced moderate TBI in male and female mice using the controlled cortical impact model and assessed outcomes 30 days post-injury. Behavioral performance was evaluated with the open field, elevated plus maze, and Barnes maze, while hippocampal oscillations, interneuron survival, protein expression (KCC2, NKCC1, p75

Indexed as

cognitive performanceGABA transmissionsex dependencetraumatrophic factor

Identifiers

PMID41069767
PMCPMC12504505

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.