Evidence map›Paper›PMID 41069762›Full record

ArticleBioactive materials2026

Thermosensitive antibacterial nanocomposite hydrogel guiding macrophage polarization and bone regeneration for periodontitis treatment.

Xiang Yu, Huiling Liu, Lingdi Chen, Xiaohui Cheng, Gang Wu, Tim Forouzanfar, Longbao Feng, Rui Guo, Miao Zhou, Ting Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. [Bioactive substances delivery for bone repair via nanocomposites: advantages, mechanisms, and emerging trends].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  11. Review
  12. Application of injectable hydrogels in the treatment of periodontitis.Frontiers in bioengineering and biotechnology · 2026
    Review
  13. Review
  14. Article
  15. Melittin-Loaded FeInternational journal of nanomedicine · 2026
    Article
  16. Stem cells international · 2026
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiang YuThe First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, 510405, China.
Huiling LiuDepartment of Oral and Maxillofacial Surgery, Leiden University Medical Center (LUMC), Leiden, 2333 ZA, the Netherlands.
Lingdi ChenHospital of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Xiaohui ChengHospital of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Gang WuSavid School of Stomatology, Hangzhou Medical College, Hangzhou, 311399, China.
Tim ForouzanfarDepartment of Oral and Maxillofacial Surgery, Leiden University Medical Center (LUMC), Leiden, 2333 ZA, the Netherlands.
Longbao FengKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Rui GuoKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Miao ZhouDepartment of Stomatology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Ting SunFoshan Stomatology Hospital & School of Medicine, Foshan University, Foshan, 528000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is a chronic inflammatory disease caused by bacterial infection that leads to the destruction of periodontal tissues. Traditional treatment involves scaling and root planing combined with antibiotics, but systemic antibiotic therapy often results in insufficient drug concentration at the treatment site and unwanted side effects. Here, we developed a nanocomposite thermosensitive hydrogel (CFMD) designed for localized drug delivery. The chitosan-grafted Pluronic® F127 hydrogel (CP) had natural antibacterial activity. After the thermosensitive material flows into the periodontal pocket, it transforms into a gel phase at body temperature, filling the periodontal pocket and preserving the nanomedicine. As the hydrogel retained in the periodontal pocket is degraded, folic acid-modified MBG nanoparticles loaded with doxycycline (FA-MBG@Dox) nanoparticles deliver doxycycline hydrochloride (Dox) to below the gum line, where instruments and hydrogel drug carriers cannot reach, enabling deeper antibacterial, anti-inflammatory, and osteogenesis-promoting effects.

Indexed as

AntibacterialAnti-inflammatoryNanocomposite hydrogelOsteogenesisPeriodontitis

Identifiers

PMID41069762
PMCPMC12506435

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.