Evidence map›Paper›PMID 41069681›Full record

ArticleFrontiers in molecular biosciences2025

Interactions between membrane-bound streptococcal alpha-enolase and human plasminogen captured through cryogenic-electron microscopy.

Sheiny Tjia-Fleck, Bradley M Readnour, Zhong Liang, Yetunde A Ayinuola, Francis J Castellino

Abstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sheiny Tjia-FleckDepartment of Chemistry and Biochemistry and W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.
Bradley M ReadnourDepartment of Chemistry and Biochemistry and W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.
Zhong LiangDepartment of Chemistry and Biochemistry and W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.
Yetunde A AyinuolaDepartment of Chemistry and Biochemistry and W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.
Francis J CastellinoDepartment of Chemistry and Biochemistry and W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.

Funding

STRUCTURE-FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR01HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 1985 to 2021
$7.9M
Plasminogen and Plasmin: Structure and FunctionR56HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 2022 to 2022
$743k
NHLBI NIH HHS R01 HL013423NHLBI NIH HHS R56 HL013423
6 · The paper itself

Abstract

Certain invasive strains of the Gram-positive bacterium

Indexed as

cryogenic electron microscopyplasminogen binding proteinsscanning electron microscopyStreptococcus pyogenes enolasetissue-type plasminogen activator

Identifiers

PMID41069681
PMCPMC12504095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.