Evidence map›Paper›PMID 41069623›Full record

ReviewJournal of oral and maxillofacial pathology : JOMFP

MALAT1 expression in oral squamous cell carcinoma - A Systematic review and meta-analysis.

Ija Mayuek, Abikshyeet Panda, Harish Kumar, Lipsa Bhuyan, Kailash Chandra Dash, Pallavi Mishra

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Non-Coding RNAs in Oral Diseases: From Pathogenesis to Clinical Translation.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ija MayuekDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, KIIT University, Kalinga Institute of Dental Sciences (KIDS), Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Abikshyeet PandaDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, KIIT University, Kalinga Institute of Dental Sciences (KIDS), Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Harish KumarDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, KIIT University, Kalinga Institute of Dental Sciences (KIDS), Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Lipsa BhuyanDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, KIIT University, Kalinga Institute of Dental Sciences (KIDS), Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Kailash Chandra DashDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, KIIT University, Kalinga Institute of Dental Sciences (KIDS), Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.
Pallavi MishraDepartment of Oral and Maxillofacial Pathology and Oral Microbiology, KIIT University, Kalinga Institute of Dental Sciences (KIDS), Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: MALAT1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1) is a long non-coding RNA that helps in disease prognosis. Objective: The aim of the study is to provide updated evidence on the expression rate of MALAT1 in oral squamous cell carcinoma (OSS) compared to normal cells and its other histopathological gradings, like well-differentiated, moderately differentiated, and poorly differentiated OSCC. Materials and Methods: The review adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in PROSPERO with the registration number CRD42024598836. A thorough search of databases was conducted from January 2000 to April 2024 to identify studies reporting the MALAT1 expression in OSCC cells compared to normal cells and its histological gradings of OSCC. Quality assessment was performed using the Newcastle Ottawa scale (NOS) for included studies. The standardized mean difference (SMD) was used for continuous outcomes, while odds ratio (OR) and risk ratio (RR) were applied for categorical outcomes, depending on the data reported. A random-effects model was used for all analyses, with statistical significance set at Results: Seven studies qualified for inclusion, with four undergoing meta-analysis. Quality assessment indicated a moderate to low risk of bias. The meta-analysis revealed increased MALAT1 expression in OSCC cells (SMD = 3.90, 1.20-6.61) compared to normal tissue. Among OSCC grades, MALAT1 expression was higher in moderately differentiated OSCC than in well-differentiated (SMD = 5.50, -15.08-26.08), lower in moderately differentiated than in poorly differentiated (SMD = 10.50, -27.16-6.61), and lower in well-differentiated than in poorly differentiated OSCC (SMD = 1.50, -2.48-0.52). No publication bias was detected in the funnel plot. Conclusion: MALAT1 is a therapeutic factor in OSCC; its increased expression is related to OSCC growth and could help control metastasis, with overall good clinical relevance, making it a promising prognostic marker for OSCC.

Indexed as

Diagnosismetastasis-associated lung adenocarcinoma transcript 1oral cancerprognosissystematic review

Identifiers

PMID41069623
PMCPMC12507374

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.