ArticleJournal of oral and maxillofacial pathology : JOMFP
Evaluation of the immunohistochemical expression of oxidative DNA damage marker 8-OHdG in oral cancer.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammation-driven carcinogenesis in oral cancer: A systematic review of cellular mechanisms and clinical perspectives.The Indian journal of medical research · 2026Pooled it
- Differential Oxidative Stress Profiles in Circulating and Peritumoral Adipose Tissue Across Stages of Colorectal Cancer.International journal of molecular sciences · 2026Article
- Obesity and oxidative stress: potential mechanisms in endometrial disorders.Frontiers in endocrinology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The present immunohistochemical investigation attempted to evaluate the concentrations of 8-hydroxy-2-deoxyguanosine (8-OHdG) as a prospective DNA damage biomarker in primary oral squamous cell carcinoma (OSCC) patients compared to healthy tissues to analyse the immunohistochemistry (IHC) staining intensity levels across different histopathological levels of OSCC. Materials and Methods: The control group consisted of tissue samples from the normal mucosa (n = 10). The study groups consisted of tissue blocks sourced from patients with primary OSCC (n = 55). The principal antibody utilised was 8-OHdG Antibody, and a control specimen was treated identically to the OSCC group but treated in non-immune serum rather than the primary antibody. The data were estimated using the Statistical Package for the Social Sciences (SPSS) version 26.0. The Fisher's exact test was employed to examine the variations between the sample groups at a 5% significance level. Results: The OSCC group had 20 well-differentiated (WD), 20 moderately differentiated (MD), and 15 poorly differentiated (PD) samples. Compared to normal tissue samples, a marked elevation of 8-OHdG antigen production was observed in OSCC tissue samples ( Conclusion: The Oxidative stress (OS) marker 8-OHdG has higher concentrations in the tissue samples with OSCC than in healthy tissues and serves as a predictive biomarker for OSCC.
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