ArticlePain research & management2025
Exploring Research Hotspots and Emerging Trends in Mitochondria and Chronic Pain: A Bibliometric and Visualized Analysis From 2004 to 2024.
Article in Pain research & management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Mitochondria play a crucial role in various cellular processes, and their dysfunction has been increasingly recognized as a significant factor in the pathophysiology of chronic pain. Despite growing interest in this area, a comprehensive bibliometric analysis of the research trends, key themes, and influential contributions in the study of mitochondria and pain has not been conducted. This study aims to fill this gap by providing a detailed overview of the research landscape from 2004 to 2024. Methods: A comprehensive literature search was performed using the Web of Science Core Collection database to identify relevant studies published between January 1, 2004, and June 24, 2024. A total of 1995 articles were identified and included in the analysis. Bibliometric tools, including CiteSpace, VOSviewer, and RStudio, were employed to analyze and visualize data related to cocitation networks, keyword co-occurrence, and clustering patterns. The analysis focused on identifying research trends, key authors, influential journals, and emerging themes within the field. Results: The analysis revealed a significant increase in research activity on mitochondria and pain, particularly after 2011, with the number of publications rising from 74 in 2015 to 171 in 2020, representing a 131% growth during this period. Key themes identified include mitochondrial dysfunction, oxidative stress, neuroinflammation, autophagy, and mitochondrial biogenesis. The United States, China, Germany, and the United Kingdom emerged as leading contributors to the field, with prominent institutions such as Harvard University and the University of California playing central roles in collaborative networks. Influential authors and foundational studies were identified through cocitation analysis, highlighting the interdisciplinary nature of the research. Conclusion: This bibliometric analysis provides a comprehensive overview of the evolving research landscape in mitochondria and pain, highlighting key trends, influential contributions, and emerging research directions. The findings underscore the growing recognition of mitochondrial dysfunction as a critical factor in pain mechanisms and suggest that future research should focus on translating basic findings into clinical practice while expanding global collaborations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.