Evidence map›Paper›PMID 41069610›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

Beyond the count: platelet dysfunction profile in pediatric trauma patients.

Ronit Kar, Erin V Feeney, Jack R Killinger, Katrina M Morgan, Devin M Dishong, Katelin C Rahn, Rassam M G Rassam, Grace A Ballentine, Philip C Spinella, Matthew D Neal and 3 more

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Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Ronit KarTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Erin V FeeneyTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jack R KillingerTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Katrina M MorganDivision of General Surgery and Trauma, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Devin M DishongTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Katelin C RahnTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rassam M G RassamTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Grace A BallentineTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Philip C SpinellaTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Matthew D NealTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Barbara A GainesDepartment of Surgery, UT Southwestern, Dallas, Texas, USA.
Susan M SheaTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Christine M LeeperTrauma and Transfusion Medicine Research Center, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Using Microfluidics to Identify Mechanisms of Platelet Dysfunction and Assess Therapeutic Efficacy in Traumatic HemorrhageK25HL161401 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Susan Marguerite Shea · 2022 to 2026
$643k
NHLBI NIH HHS K25 HL161401
6 · The paper itself

Abstract

Background: Existing clinical coagulation assays are inadequate to evaluate posttraumatic platelet dysfunction in children. Objectives: To elucidate changes in flow-dependent platelet function after injury in children using a microfluidic assay. Methods: We enrolled 18 children who presented with highest-acuity trauma activation and 10 healthy children at an academic pediatric center. For the control cohort, outpatient blood samples were collected, and for the trauma cohort, blood was collected in the trauma bay for conventional coagulation tests, thromboelastography, von Willebrand factor A1 domain activity, and a microfluidic assay using a stenotic channel (shear rate = 3500 s Results: The trauma cohort characteristics were 67% male, median (IQR) age 6 years (4-12), median (IQR) injury severity score 17 (9-26), and 78% blunt mechanism. In total, 50% required blood transfusion and 11% (2/18) died. While thromboelastography maximum amplitude (59.9 ± 6.1 mm) and platelet counts (306.3 ± 111.1 × 10 Conclusion: Posttraumatic platelet dysfunction was observed by utilizing a microfluidic assay in a pediatric trauma cohort. Further study is needed to understand the underlying mechanisms and significance of posttraumatic platelet dysfunction in children.

Indexed as

Hemostasismicrofluidicspediatricsplateletstrauma-induced coagulopathy

Identifiers

PMID41069610
PMCPMC12506559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.