ArticleOpen forum infectious diseases2025
Global Estimates of the HPV-related, Noncervical Cancer Burden in People With HIV and AIDS and the Potential Effect of Improved HPV Vaccine Coverage in This Population: A Systematic Review, Meta-analysis and Modeling Study.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Alcohol consumption and oral human papillomavirus infection among men living with HIV: a cross-sectional study from the ULACNet 201 trial.Scientific reports · 2026Trial
- From Divergent Guidelines to Delphi-Ready Items: Tutorial for Large Language Model-Assisted Guideline Harmonization Using Penile Cancer as a Worked Example.Journal of medical Internet research · 2026Article
- The Cervical Cancer Paradox in Eastern Europe: How Knowledge and Institutional Trust Shape HPV Vaccination Attitudes in Romania.Medical sciences (Basel, Switzerland) · 2026Observational
- Human Papillomavirus-Related Cancer in People With HIV and Solid Organ Transplant Recipients.JAMA network open · 2026Article
- Article
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Authors and funding
7 authors.
Funding
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Abstract
Background: While HIV/HPV coinfection significantly increases cervical carcinogenesis, the relationship with HPV-related noncervical cancers is less understood. HPV vaccination is key in prevention, but global coverage is low (21%). We aimed to quantify the risk of noncervical cancers among people living with HIV and AIDs (PWHA), estimate this cancer burden globally, and the impact of improved HPV vaccine coverage. Methods: We conducted a systematic review and meta-analysis of 3 databases to identify studies comparing HPV-related noncervical cancer risk in PWHA and HIV negative populations, generating a risk ratio for each cancer. This was combined with country-specific HIV prevalence and the incidence of cancer cases to calculate the burden. Vaccine impact was estimated using vaccine coverage data and point efficacy estimates. Results: 25 studies were included analyzing 1 560 923 million PWHA. The risk of developing each HPV-related noncervical cancer was significantly increased in PWHA. The pooled risk was 30.32 (CI 20.54-44.75) for anal, 15.78 (CI 4.62-53.92) for vaginal, 6.99 (CI 3.37-14.51) for vulvar, 6.37 (CI 3.98-10.21) for penile, and 2.74 (CI 2.10-3.58) for oropharyngeal cancers. Globally, 30% of cases in Africa were HIV-attributable, compared with 5% worldwide. If HPV vaccination coverage increased to 90%, we could prevent 1987 more cancer cases, assuming 50% vaccine efficacy. Conclusions: This meta-analysis confirms that PWHA are more susceptible to adverse outcomes beyond cervical cancer and must be prioritized in HPV prevention and vaccine efficacy research. In countries with high HIV/HPV coinfection prevalence, integrating HPV vaccination with HIV services could minimize disparities in the cancer burden worldwide.
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