Evidence map›Paper›PMID 41069541›Full record

ArticleActa endocrinologica (Bucharest, Romania : 2005)

EFFECTS OF VARIATIONS IN BONE METABOLISM RELATED GENES ON BONE MINERAL DENSITY OF PATIENTS WITH OSTEOPOROSIS.

A M Güler, Z Emrence, E N Bozdağ, F Paçal, N Abacı, R Tanakol, S S Ekmekci

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In one paragraph

Article in Acta endocrinologica (Bucharest, Romania : 2005). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A M GülerIstanbul University, Aziz Sancar Institute of Experimental Medicine, Dept. of Genetics, Istanbul, Turkiye.
Z EmrenceIstanbul University, Aziz Sancar Institute of Experimental Medicine, Dept. of Genetics, Istanbul, Turkiye.
E N BozdağIstanbul University, Aziz Sancar Institute of Experimental Medicine, Dept. of Genetics, Istanbul, Turkiye.
F PaçalIstanbul University, Aziz Sancar Institute of Experimental Medicine, Dept. of Genetics, Istanbul, Turkiye.
N AbacıIstanbul University, Aziz Sancar Institute of Experimental Medicine, Dept. of Genetics, Istanbul, Turkiye.
R TanakolIstanbul University, Istanbul Medical Faculty, Dept. of Internal Medicine, Division of Endocrinology and Metabolism, Istanbul, Turkiye.
S S EkmekciIstanbul University, Aziz Sancar Institute of Experimental Medicine, Dept. of Genetics, Istanbul, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Osteoporosis is a complex disease and its development is influenced by genetic, epigenetic, metabolic, and environmental factors. However, specific genetic factors associated with osteoporosis are not fully understood. The aim of this study was to identify genetic risk factors for osteoporosis. Methods: This study included 86 females with osteoporosis and 47 healthy females. We analyzed rs1800587, rs16944, rs1799814, rs4988321, rs2228570, and rs35211496 variations in IL1A, IL1B, CYP1A1, LRP5, VDR, and RANK, respectively, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Our analysis revealed that the CT and TT genotype for rs1800587 in IL1A was associated with higher bone mineral density in the lumbar spine, trochanter, Ward's triangle, and femoral neck (p=0.020, p=0.021, p=0.015, and p=0.013, respectively). The rs1800587 variation in IL1A was associated with a reduced risk of osteoporosis in both dominant and codominant inheritance models (CC Conclusion: Our findings suggest that the rs1800587 variation in IL1A gene is associated with a significantly decreased risk of osteoporosis in the Turkish population.

Indexed as

bone mineral densitygene variationinterleukin 1alphaOsteoporosis

Identifiers

PMID41069541
PMCPMC12506868

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.