Evidence map›Paper›PMID 41069518›Full record

ArticleFrontiers in neuroscience2025

Pathological respiratory chemoreflex activation predicts improvement of neurocognitive function in response to continuous positive airway pressure therapy.

Yu-Tong Hu, Yue-Nan Ni, Hugi Hilmisson, Robert Joseph Thomas

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Yu-Tong HuDepartment of Respiratory, Critical Care and Sleep Medicine, West China School of Medicine and West China Hospital, Sichuan University, Chengdu, China.
Yue-Nan NiDepartment of Respiratory, Critical Care and Sleep Medicine, West China School of Medicine and West China Hospital, Sichuan University, Chengdu, China.
Hugi HilmissonMyCardio-LLC, Denver, CO, United States.
Robert Joseph ThomasDivision of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States.

Funding

APPLES: Apnea Positive Pressure Long-Term Efficacy StudyU01HL068060 · NHLBI · STANFORD UNIVERSITY · PI KUSHIDA, CLETE A · 2002 to 2007
$14.1M
National Sleep Research Resource (NSRR)R24HL114473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S., ZHANG, GUO-QIANG · 2013 to 2017
$7.5M
NHLBI NIH HHS R24 HL114473NHLBI NIH HHS U01 HL068060
6 · The paper itself

Abstract

Introduction: There is a need for biomarkers predicting neurocognitive improvement following treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP). The role of sleep apnea endotypes as predictors are promising. Objective: To assess the relationship between a high loop gain biomarker, elevated low frequency narrow band (e-LFC Methods: The e-LFC Results: A total of 362 subjects received CPAP and had e-LFC Conclusion: e-LFC

Indexed as

cardiopulmonary couplinghigh loop gainneurocognitive functionpositive airway pressuresleep apnea

Identifiers

PMID41069518
PMCPMC12504490

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.