ArticleThe South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa2025
Prevalence of neurocognitive impairments in adults with chronic pain: A cross-sectional study.
Article in The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Aberrant CX3CL1-CX3CR1 Signaling Reprograms Microglial Exosome Secretion via KIFC2 to Drive Cognitive Impairment in Chronic Pain.International journal of molecular sciences · 2026Article
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Abstract
Background: There is a strong link between chronic pain and neurocognitive impairment. The co-occurrence of the two disorders often leads to a poor quality of life and significant disability. Aim: To determine the prevalence of neurocognitive impairments in adults with chronic pain. Setting: The study was conducted at a tertiary hospital in Pietermaritzburg, KwaZulu-Natal. Methods: This cross-sectional study was conducted at a pain clinic within a tertiary hospital in Pietermaritzburg, KwaZulu-Natal. Participants were required to be clinic attendees, proficient in English, and have a minimum of a Grade 7 education. Exclusion criteria included neurological disorders, significant language barriers, or ineligible age. Recruitment used purposive sampling with informed consent. Data were collected using socio-demographic and clinical questionnaires, namely, the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and the Physical Self-Maintenance Scale (PSMS). The primary outcome was the prevalence of neurocognitive impairment; secondary outcomes examined associations with demographic and clinical factors using both descriptive and inferential statistics. Results: A total of 105 participants (59 females and 46 males) were enrolled in the study. The mean age of the participants was 55.1 ± 6.75 years. A total of 73.3% ( Conclusion: Chronic pain is associated with impairments in neurocognitive performance, particularly in short-term memory and executive functioning. Contribution: A significant correlation was found between lower education levels and neurocognitive impairment (
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