Evidence map›Paper›PMID 41069465›Full record

ArticleFrontiers in plant science2025

Exogenous α-lipoic acid mitigates lead (Pb) toxicity in tomato seedlings by regulating metabolites, nutrient uptake, antioxidant defense and redox balance maintenance.

Khaled M A Ramadan, Sallah A Al Hashedi, Adil AlShoaibi, Muhammad Naeem Sattar, Doaa Bahaa Eldin Darwish, Khulud S Albalawi, Fahad Mohammed Alzuaibr, Eslam S A Bendary, Hala B Khalil, Hesham S Ghazzawy and 2 more

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In one paragraph

Article in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Khaled M A RamadanCentral Laboratories, Department of Chemistry, King Faisal University, Al-Ahsa, Saudi Arabia.
Sallah A Al HashediCentral Laboratories, Department of Chemistry, King Faisal University, Al-Ahsa, Saudi Arabia.
Adil AlShoaibiPhysics Department, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.
Muhammad Naeem SattarCentral Laboratories, Department of Chemistry, King Faisal University, Al-Ahsa, Saudi Arabia.
Doaa Bahaa Eldin DarwishDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Khulud S AlbalawiDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Fahad Mohammed AlzuaibrDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Eslam S A BendaryDepartment of Agricultural Biochemistry, Faculty of Agriculture, Ain Shams University, Hadayek Shobra, Cairo, Egypt.
Hala B KhalilBiological Sciences Department, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia.
Hesham S GhazzawyDate Palm Research Center of Excellence, King Faisal University, Al-Ahsa, Saudi Arabia.
Mahmoud Adel Ahmed AliHorticultural Department, Faculty of Agriculture, Ain Shams University, Hadayek Shobra, Cairo, Egypt.
Mohamed F M IbrahimDepartment of Agricultural Botany, Faculty of Agriculture, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Water contamination with heavy metals drastically affects plant growth and development. It is more dangerous than other contamination sources due to its cumulative impact over time through plant irrigation. Lead (Pb) is one of the most prevalent and hazardous heavy metals that significantly impede plant growth and development in terrestrial ecosystems. α- lipoic acid (ALA) is a naturally occurring dithiol antioxidant, strong ROS scavenger and metal chelator. Herein, this study was conducted to explore the role of exogenous ALA (0.1 mM) in reducing the Pb-phytotoxicity in tomato seedlings irrigated with Pb contaminated water (250 ppm for 45 days after transplanting). Exposing plants to Pb stress significantly inhibited plant growth, photosynthetic pigments, mineral homeostasis and cell membrane integrity compared to the control plants. In contrast, ALA application markedly revealed a significant improvement in these traits by reinforcing the antioxidant defense systems including superoxide dismutase, guaiacol peroxidase, catalase, glutathione reductase and the major reduced components of ascorbate glutathione cycle. Moreover, ALA significantly enhanced N, P, K, Ca and Fe, reduced Pb uptake and restricted the Pb-induced oxidative damage by reducing the hydrogen peroxide, malondialdehyde and inhibiting the activity of Lipoxygenase. The regression analysis exhibited that ALA demonstrated various significant relationships between the uptake of Pb and the major components of ascorbate glutathione cycle in both leaf and root. In conclusion, our findings deciphered the potential functions of ALA in alleviating Pb-phytotoxicity and enhancing the redox balance of tomato seedlings by enhancing the ratio between the reduced glutathione/oxidized glutathione and reduced ascorbate/dehydroascorbate.

Indexed as

ascorbate–glutathione cycleheavy metalslead toxicityreactive oxygen species (ROS) and redox balanceSolanum lycopersicum L.water contamination

Identifiers

PMID41069465
PMCPMC12504201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.