ArticleCrystal growth & design2025
Effect of Surfactants on Posaconazole Crystallization and Polymorphism: Tween 80 vs Span 80.
Article in Crystal growth & design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A surfactant is often present in a pharmaceutical formulation and can accelerate the crystallization of the active component. We investigate the effects of two common surfactants with different hydrophilic-lipophilic balance, Span 80 and Tween 80, on the crystallization of posaconazole (POS) in its two polymorphic forms (I and II). At 0-10 wt %, the two surfactants similarly increase the growth rates of both polymorphs, but have different effects on their nucleation rates, without exhibiting the proportional-modification behavior observed for many other amorphous systems. The classical nucleation theory (CNT) can quantitatively describe the nucleation kinetics in the pure POS melt and in the surfactant-doped melts, where the surfactants are treated as ideal diluents of POS. The two surfactants' effects on the nucleation rate form a single trend in the CNT analysis, yielding the nucleus/liquid interfacial tension σ = 0.019 J/m
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