ArticleBrain communications2025
Glymphatic dysfunction as a potential driver of cerebral iron deposition in Parkinson's disease.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Impaired Glymphatic Function and Post-stroke Cognitive Decline after Intracerebral Hemorrhage: A Serial Neuroimaging Study.Translational stroke research · 2026Article
- Alterations in the DTI-ALPS index and choroid plexus volume are associated with symptom severity in children with tic disorders.BMC neurology · 2026Article
- The role of glymphatic system in brain injury after subarachnoid hemorrhage.Frontiers in immunology · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral iron deposition is a pathological hallmark of Parkinson's disease. Notably, Parkinson's disease patients exhibit the characteristic neuroimaging features of enlarged choroid plexus volume (CPV) and diminished glymphatic function. While previous research has focused on potential iron influx dysregulation in Parkinson's disease, the critical question of whether impaired iron clearance stemming from choroid plexus and glymphatic system dysfunction constitutes a key mechanism underlying pathological iron accumulation remains unexplored. Therefore, the aim of this study was to investigate the relationship between cerebral iron deposition and glymphatic dysfunction in Parkinson's disease, and explored its clinical relevance. We hypothesized that impaired glymphatic clearance contributes to pathological iron accumulation in Parkinson's disease. This cross-sectional study enrolled 65 patients with mild-to-moderate Parkinson's disease and 38 age- and sex-matched healthy controls. Multimodal MRI was used to assess the CPV, diffusion tensor imaging analysis along the perivascular space (ALPS) index (indirectly reflecting glymphatic function) and quantitative susceptibility mapping-derived iron levels. The clinical evaluations included motor, cognitive and psychiatric assessments. Statistical analyses compared group differences, correlations, mediation effects and diagnostic performance via receiver operating characteristic analysis. Compared to healthy controls, Parkinson's disease patients exhibited bilateral CPV enlargement (
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