ArticleCurrent developments in nutrition2025
The Relationship Between Blood Lipidomics and Cardiotoxic Injury Following Acute Exposure to Anthracycline Chemotherapy in Women With Breast Cancer: A Feasibility Study.
Article in Current developments in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Anthracycline chemotherapy (AC) leads to cardiotoxicity in many patients with breast cancer by inducing inner mitochondrial damage and disrupting the electron transport chain. It is unclear why some, but not all, women who undergo AC develop chronic cardiac dysfunction. Objectives: The aim of this prospective feasibility study was to determine accrual rate and estimate the effect size of 1 cycle of AC on myocardial injury and blood lipidome changes in women with breast cancer. Methods: Fourteen women with breast cancer planning to undergo AC enrolled and underwent cardiac magnetic resonance (CMR) imaging and blood sampling across 2 visits, before and after any 1 cycle of AC in the treatment regimen. Fatty acid composition of red blood cells (RBCs) and cardiolipin (CL) in peripheral blood mononuclear cells were measured. Exploratory analyses were conducted. Results: Myocardial edema, obtained via T2 mapping using CMR, increased after 1 cycle of AC in women with breast cancer. The ratio of tetralinoleoyl (LA Conclusions: OA
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