Evidence map›Paper›PMID 41069412›Full record

ReviewFrontiers in bioengineering and biotechnology2025

Extracellular vesicles isolation: a focus on magnetic beads-assisted platforms.

Xinghao Lan, Danyu Li, Yancong Yu, Sumedha Nitin Prabhu, Guozhen Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinghao Lan *Integrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHK(SZ)-Boyalife Joint Laboratory for Regenerative Medicine Engineering, Biomedical Engineering Program, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.
Danyu Li *Integrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHK(SZ)-Boyalife Joint Laboratory for Regenerative Medicine Engineering, Biomedical Engineering Program, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.
Yancong YuIntegrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHK(SZ)-Boyalife Joint Laboratory for Regenerative Medicine Engineering, Biomedical Engineering Program, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.
Sumedha Nitin PrabhuIntegrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHK(SZ)-Boyalife Joint Laboratory for Regenerative Medicine Engineering, Biomedical Engineering Program, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.
Guozhen LiuIntegrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHK(SZ)-Boyalife Joint Laboratory for Regenerative Medicine Engineering, Biomedical Engineering Program, School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) play a crucial role in cellular communication and hold significant potential for diagnostic and therapeutic applications. However, the efficient isolation of EVs remains a challenge due to their heterogeneity and the presence of contaminating particles. Traditional isolation techniques, such as ultracentrifugation and size-exclusion chromatography, often result in low yield and purity. This review focuses on magnetic bead-assisted platforms as a promising approach to overcome these limitations. Magnetic beads (MBs) offer high specificity, reproducibility, and efficiency in EVs isolation, enhancing their utility in biomedical research and clinical applications. The synthesis and surface modification strategies of MBs are discussed. Additionally, advancements in microfluidic-integrated platforms and multiplex bead-based assays for EVs isolation are explored. The review highlights strategies to optimize EVs capture efficiency and outlines future directions for standardizing magnetic bead-based isolation protocols to improve their applicability in precision medicine.

Indexed as

affinity-based isolationevs isolationextracellular vesiclesmagnetic beadsmagnetic beads synthesismicrofluidics

Identifiers

PMID41069412
PMCPMC12504249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.