ReviewRSC advances2025
Progress in the design of ascorbic acid derivative-mediated drug delivery.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- PEGylated Flavonoid Aspasomes as a Brain-Targeted Nano-Vesicular Platform for Enhanced Neuroprotection in Stress-Induced Cognitive Dysfunction.AAPS PharmSciTech · 2026Article
- Botanical and Upcycled Bioactives for Advanced Topical Formulations: Mechanistic Pathways, Cutaneous Delivery, and Sustainability-by-Design.Pharmaceutics · 2026Review
- In Vitro Antioxidant and Cellular Activities of Functionalized Spermidine by Conjugating with Ascorbic Acid in Human Skin Cells.Molecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antioxidant-based pharmaceutical products are currently experiencing a surge in popularity and satisfaction, demonstrating promising preclinical and clinical prospects. These products exert their beneficial effects by displaying protection against mischievous free radicals. One potent antioxidant is ascorbic acid (AA), which plays numerous crucial biochemical roles and is typically distinguished as a primary hydrophilic, non-enzymatic antioxidant in tissues. AA is a water-soluble essential antioxidant vitamin that can only be obtained from the diet. However, AA's instability, coupled with challenges related to its delivery, has presented formulation challenges for chemists. As a result, various stable hydrophilic and lipophilic derivatizations of AA have been devised. Capitalizing on their potential, delivery platforms, particularly nano-sized ones utilizing ascorbic acid derivatives, have been extensively investigated in recent years. Two such derivatives, namely, ascorbyl-6-palmitate (AP; a lipophilic derivative) and ascorbyl-2-glucoside (AA-2G; a hydrophilic derivative), have been extensively studied in previous works. Herein, the scientific data related to their utilization, either as a drug or as an integral component in delivery vehicles, and their pharmaceutical applications are evaluated.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.