Evidence map›Paper›PMID 41069160›Full record

ReviewAnnals of medicine2025

Biological roles and potential clinical value of tRNA-derived small RNAs in gastrointestinal malignancies.

Yongfu Shao, Xuan Yu, Weihong Zhou, Jianing Yan, Haotian Dong, Guoliang Ye

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07265271 (Project for Multi-Omics-Based Early Detection of Hepatocellular Carcinoma), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07265271 recruitingnot on this map

Project for Multi-Omics-Based Early Detection of Hepatocellular Carcinoma (PROMETHEA Study)

TypeobservationalSponsorCity of Hope Medical CenterRan2025 to 2028Enrolled600ConditionsHepatocellular Carcinoma (HCC)ArmsSmall RNA sequence, Rt-qPCR
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Impact of CaInternational journal of molecular sciences · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yongfu ShaoDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Xuan YuHealth Science Center, Ningbo University, Ningbo, China.
Weihong ZhouDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Jianing YanDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Haotian DongDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Guoliang YeDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

tRNA-derived small RNAs (tsRNAs) are small RNA fragments generated from tRNA molecules or their precursors through cleavage by enzymes such as Dicer. As noncoding small RNAs, tsRNAs have important biological functions, including regulating mRNA stability and protein translation, serving as epigenetic regulators, and participating in intercellular communication. Recent studies have indicated that the dysregulation of tsRNAs is closely linked to the occurrence and progression of gastrointestinal malignancies. Increasing evidence suggests that abnormally expressed tsRNAs play crucial roles in various mechanisms related to the proliferation, differentiation, apoptosis, invasion, metastasis, cellular metabolism, immune evasion and angiogenesis of gastrointestinal malignancies. The vast quantity, high abundance, diverse functions and tissue- and disease-specific expression of tsRNAs make them promising gastrointestinal malignancy biomarkers in terms of clinical screening, prognostic assessment and gene therapy. The biological roles and potential clinical value of tsRNAs offer novel insights into the prevention and treatment of gastrointestinal malignancies.

Indexed as

Gastrointestinal NeoplasmsRNA, Small UntranslatedRNA, TransferApoptosisBiomarkers, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansPrognosisBiomarkers, TumorRNA, Small UntranslatedRNA, Transferbiomarkerclinical significancefunctional mechanismsGastrointestinal malignanciestsRNAs

Identifiers

PMID41069160
PMCPMC12517428

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.