SynthesisJournal of cachexia, sarcopenia and muscle2025
Sarcopenia and Its Individual Traits Independently Predict Mortality in Patients on Dialysis: A Systematic Review and Meta-Analysis.
Synthesis in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sarcopenia and Its Individual Traits Independently Predict Mortality in Patients on Dialysis: A Systematic Review and Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Physical function, exercise, and clinical outcomes in peritoneal dialysis: a narrative review.International journal of nursing studies advances · 2026Review
- 101 machine learning algorithms for predicting mortality in critically ill patients with spinal cord injury and sarcopenia: a multi-database study.BMC medical informatics and decision making · 2026Observational
- Muscle ultrasound and shear wave elastography for screening sarcopenia in patients undergoing maintenance hemodialysis: a prospective study.Frontiers in medicine · 2026Article
- Clinical utility of the AITIS model for test-free identification of sarcopenia in patients with stage IV-V non-dialysis-dependent chronic kidney disease.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundLoss of muscle mass, muscle weakness and the combination of the two are commonly observed in patients on dialysis and may have a negative impact on their survival. In this systematic review and meta-analysis (MA), we evaluated the consistency and strength of the association between mortality risk and the presence of low muscle mass with adequate muscle strength, low muscle strength with adequate muscle mass and sarcopenia (low muscle mass and strength combined) in patients on dialysis. Ultimately, we aimed to grade which of these three conditions had the strongest association with increased mortality risk in this vulnerable group of patients.
methodsWe searched for studies published until 31 January 2024 that evaluated sarcopenia and its individual components in patients aged > 18 years on dialysis (haemodialysis and peritoneal dialysis) and that had a mean follow-up for mortality for ≥ 12 months. Included studies had to enable the evaluation of sarcopenia traits to identify patients with low muscle mass and adequate muscle strength, low muscle strength with adequate muscle mass, and sarcopenia. A systematic search was conducted in MEDLINE (by PubMed), Embase, Web of Science, Lilacs and grey literature (i.e., Google Scholar and ProQuest). We estimated consistency in the association between sarcopenia traits and death using random effects MA and reporting hazard ratio (HR) with a 95% confidence interval (95% CI).
resultsThe electronic search retrieved 5712 records. After removing duplicated records and those that did not meet the eligibility criteria, 19 studies were included in the qualitative synthesis (4281 participants) and 17 studies (4024 participants) with extractable data for the MA. The MA showed low heterogeneity in the association between muscle parameters and sarcopenia with the risk of death: low muscle mass with adequate muscle strength, HR: 1.49; 95% CI: 1.04 to 2.13; I
conclusionAlthough being statistically significant, the association between low muscle mass and mortality seems to be less strong than the association between low muscle strength and mortality in patients on dialysis. Those presenting with a combination of the two traits, that is, sarcopenia, showed the highest risk of dying prematurely.
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